Anti-tumor Responses Induced by Chemokine CCL19 Transfected into an Ovarian Carcinoma Model via Fiber-Mutant Adenovirus Vector
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چکیده
منابع مشابه
Modulation of adenovirus vector tropism via incorporation of polypeptide ligands into the fiber protein.
The efficacy of adenovirus (Ad)-based gene therapy might be significantly improved if viral vectors capable of tissue-specific gene delivery could be developed. Previous attempts to genetically modify the tropism of Ad vectors have been only partially successful, largely due to the limited repertoire of ligands that can be incorporated into the Ad capsid. Early studies identified stringent size...
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Dendritic cells (DC) are professional antigen-presenting cells with a key function in the immune system as initiators of T-cell responses against microbial pathogens and tumors. Therefore, the immunization using DC loaded with tumor-associated antigens is potential to represent a powerful method of inducing anti-tumor immunity. Recent studies have demonstrated the usefulness of DC genetically m...
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The antitumor efficacy of EBV-induced molecule 1 ligand CC chemokine (ELC/CCL19) was evaluated in a murine lung cancer model. The ability of ELC/CCL19 to chemoattract both dendritic cells and T lymphocytes formed the rationale for this study. Compared with diluent-treated tumor-bearing mice, intratumoral injection of recombinant ELC/CCL19 led to significant systemic reduction in tumor volumes (...
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An anti-tumor immune response is one of the most important factors that can determine treatment response and prognosis of cancer patients. Recent studies have demonstrated that radiotherapy can activate tumor-specific immune responses and that these responses contribute to the therapeutic efficacy. However, the exact mechanisms underlying the radiation-induced immune responses remain unclear. B...
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conclusions these results exhibited the immuno potentiator effects of mip-3beta plasmid when coadministrated with the hcv core dna vaccine. complimentary studies integrating mip-3beta as a genetic adjuvant in hcv-core-dna vaccination models are warranted. results mice covaccinated with mip-3beta elicited an enhanced th1 biased systemic immune response as evidenced by higher ifn-γ/il-4 and anti-...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2005
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.28.1066